Diagnosis of malaria by detection of Plasmodium falciparum HRP-2 antigen with a rapid dipstick antigen-capture assay

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Diagnosis of malaria by detection of Plasmodium falciparum HRP-2 antigen with a rapid dipstick antigen-capture assay.

Two field studies in Kenya and an experimental challenge study in the USA were done to assess the accuracy of a dipstick antigen-capture assay based on qualitative detection of Plasmodium falciparum histidine-rich protein 2 (PfHRP-2) in peripheral blood for diagnosis of P falciparum infection. In these studies, the assay was 96.5-100% sensitive for detection of greater than 60 P falciparum asex...

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Evaluation of a rapid and inexpensive dipstick assay for the diagnosis of Plasmodium falciparum malaria.

Rapid, accurate and affordable methods are needed for the diagnosis of malaria. Reported here is an evaluation of a new immunochromatographic strip, the PATH Falciparum Malaria IC Strip, which is impregnated with an immobilized IgM monoclonal antibody that binds to the HRP-II antigen of Plasmodium falciparum. In contrast to other commercially available kits marketed for the rapid diagnosis of f...

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Field Evaluation of an Antigen Detection Immunochromatographic Test for Diagnosis of Plasmodium falciparum Malaria in India

An immunochromatographic test (ICT Malaria P. f.) based on the detection of Plasmodium falciparum HRP-II antigen was evaluated in Gujarat state, India. Whole blood of 148 clinically suspected malaria patients was tested blind by microscopy and ICT simultaneously. Compared with the examination of Giemsa stained thick blood films, ICT test was 99% specific and 92% efficient. It was 100% sensitive...

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ژورنال

عنوان ژورنال: The Lancet

سال: 1994

ISSN: 0140-6736

DOI: 10.1016/s0140-6736(94)91520-2